Fig. 3. mRNA vaccines are able to induce high spike protein-specific antibody binding to FcRs across all SARS-CoV-2 VOCs.

Univariate comparisons between BNT162b2 (blue) vaccine recipients, mRNA-1273 (red) vaccine recipients, and convalescent individuals (green) are shown for RBD-specific (top row) and full-length spike (S) protein-specific (bottom row) IgG1, IgG2, IgG3, IgA1, and IgM titers as well as FcγR binding. Comparisons are shown for SARS-CoV-2 D614G and indicated VOCs. Lines connect median values for each cohort. Comparisons were made for each variant using Wilcoxon rank-sum tests and corrected for multiple comparisons using the Benjamini Hochberg (BH) method. T Adjusted p-values are indicated as ***p < 0.001, **p < 0.01, and *p < 0.05.