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. Author manuscript; available in PMC: 2022 Jul 12.
Published in final edited form as: Nat Synth. 2022 Jan 12;1(1):18–23. doi: 10.1038/s44160-021-00008-x

Figure 2: Representative examples of cofactor adaptation for abiological reactions with new-to-nature reactivity modes.

Figure 2:

(a) The chemistry of metal porphyrins has been extended to hemoproteins for both carbene and nitrene transfer when presented with carbene and nitrene precursors.24–31 (b) Visible-light stimuli allows for flavoproteins to engage in biocatalytic photoredox transformations of alkyl halides.32–34 (c) Carbonic anhydrase uses silanes to generate an active zinc hydride intermediate for new reactions.38 His, histidine.