Table 1.
Top 20 downregulated Cancer Census genes in pegvisomant-treated PTEN-CaP2 xenografts
| Gene symbol | Gene name | Log2 fold change | Corrected P |
|---|---|---|---|
| Sox2 | SRY (sex determining region Y)-box 2 | –6.592 | 8.511 × 10–7 |
| Hmga1 | High mobility group AT-hook 1 | –4.250 | 7.142 × 10–10 |
| Igf2bp2 | Insulin-like growth factor 2 mRNA binding protein 2 | –3.966 | 2.001 × 10–7 |
| Hmga2 | High mobility group AT-hook 2 | –3.164 | 1.741 × 10−4 |
| Acsl6 | Acyl-CoA synthetase long-chain family member 6 | –2.596 | 5.372 × 10−5 |
| Braf | Braf transforming gene | –2.593 | 3.269 × 10−4 |
| Etv4 | Ets variant 4 | –2.305 | 2.950 × 10−3 |
| Prf1 | Perforin 1 (pore forming protein) | –2.267 | 1.893 × 10−3 |
| Ccnd1 | Cyclin D1 | –2.106 | 1.617 × 10−5 |
| Plag1 | Pleiomorphic adenoma gene 1 | –1.882 | 5.399 × 10−4 |
| Ccnd2 | Cyclin D2 | –1.828 | 4.403 × 10−3 |
| Fance | Fanconi anemia, complementation group E | –1.602 | 3.528 × 10−3 |
| Etv5 | Ets variant 5 | –1.503 | 5.043 × 10−4 |
| Mitf | Melanogenesis-associated transcription factor | –1.503 | 1.421 × 10–9 |
| Pparg | Peroxisome proliferator activated receptor γ | –1.408 | 5.117 × 10−3 |
| Casp3 | Caspase 3 | –1.394 | 6.191 × 10−3 |
| Acsl3 | Acyl-CoA synthetase long-chain family member 3 | –1.364 | 1.484 × 10−3 |
| Ddit3 | DNA-damage inducible transcript 3 | –1.349 | 9.979 × 10−4 |
| Map2k1 | Mitogen-activated protein kinase 1 | –1.251 | 5.297 × 10−3 |
| Msi2 | Musashi RNA-binding protein 2 | –1.186 | 6.001 × 10−5 |
Abbreviation: mRNA, messenger RNA.