Table 3.
Top 20 downregulated C2 gene sets in response to pegvisomant treatment in PTEN-CaP2 xenografts
| Pathway name | Log2 fold change | Corrected P |
|---|---|---|
| KEGG_RIBOSOME | –1.437 | 2.731 × 10−3 |
| REACTOME_EUKARYOTIC_TRANSLATION_ELONGATION | –1.436 | 2.731 × 10−3 |
| REACTOME_RESPONSE_OF_EIF2AK4_GCN2_TO_AMINO_ACID_DEFICIENCY | –1.409 | 2.731 × 10−3 |
| REACTOME_UPTAKE_AND_FUNCTION_OF_DIPHTHERIA_TOXIN | –1.393 | 2.829 × 10−3 |
| REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | –1.387 | 2.731 × 10−3 |
| DER_IFN_ALPHA_RESPONSE_DN | –1.361 | 2.731 × 10−3 |
| REACTOME_EUKARYOTIC_TRANSLATION_INITIATION | –1.324 | 2.731 × 10−3 |
| REACTOME_NONSENSE_MEDIATED_DECAY_NMD | –1.304 | 2.731 × 10−3 |
| REACTOME_FOLDING_OF_ACTIN_BY_CCT_TRIC | –1.303 | 3.152 × 10−3 |
| BILANGES_SERUM_AND_RAPAMYCIN_SENSITIVE_GENES | –1.283 | 2.874 × 10−3 |
| REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S | –1.222 | 2.874 × 10−3 |
| REACTOME_SUMO_IS_CONJUGATED_TO_E1_UBA2_SAE1 | –1.213 | 3.177 × 10−3 |
| BIOCARTA_SUMO_PATHWAY | –1.212 | 3.177 × 10−3 |
| REACTOME_SELENOAMINO_ACID_METABOLISM | –1.211 | 2.874 × 10−3 |
| BIOCARTA_RAN_PATHWAY | –1.209 | 3.177 × 10−3 |
| RODRIGUES_DCC_TARGETS_UP | –1.209 | 3.152 × 10−3 |
| REACTOME_INFLUENZA_INFECTION | –1.189 | 2.874 × 10−3 |
| REACTOME_RECYCLING_OF_EIF2_GDP | –1.187 | 3.152 × 10−3 |
| KEGG_PROTEASOME | –1.180 | 3.129 × 10−3 |
| FU_INTERACT_WITH_ALKBH8 | –1.178 | 3.177 × 10−3 |