Table 4.
Top 20 upregulated C2 gene sets in response to pegvisomant treatment in PTEN-CaP2 xenografts
| Pathway name | Log2 fold change | Corrected P |
|---|---|---|
| REACTOME_CYP2E1_REACTIONS | 1.477 | 2.731 × 10−3 |
| REACTOME_ORGANIC_ANION_TRANSPORT | 1.450 | 2.874 × 10−3 |
| REACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS | 1.416 | 3.051 × 10−3 |
| REACTOME_VITAMINS | 1.393 | 2.731 × 10−3 |
| REACTOME_DIGESTION_OF_DIETARY_LIPID | 1.375 | 2.874 × 10−3 |
| REACTOME_BIOSYNTHESIS_OF_MARESINS | 1.373 | 3.152 × 10−3 |
| REACTOME_SYNTHESIS_OF_EPOXY_EET_AND_DIHYDROXYEICOSATRIENOIC_ACIDS_DHET | 1.344 | 3.152 × 10−3 |
| REACTOME_XENOBIOTICS | 1.292 | 2.874 × 10−3 |
| REACTOME_SODIUM_COUPLED_SULPHATE_DI_AND_TRI_CARBOXYLATE_TRANSPORTERS | 1.291 | 3.278 × 10−3 |
| REACTOME_HIGHLY_SODIUM_PERMEABLE_POSTSYNAPTIC_ACETYLCHOLINE_NICOTINIC_RECEPTORS | 1.275 | 2.874 × 10−3 |
| PASTURAL_RIZ1_TARGETS_DN | 1.241 | 3.177 × 10−3 |
| REACTOME_TYROSINE_CATABOLISM | 1.224 | 3.152 × 10−3 |
| TUOMISTO_TUMOR_SUPPRESSION_BY_COL13A1_DN | 1.224 | 2.874 × 10−3 |
| REACTOME_CHOLINE_CATABOLISM | 1.217 | 2.874 × 10−3 |
| REACTOME_SIGNALING_BY_MST1 | 1.211 | 4.614 × 10−3 |
| REACTOME_INTESTINAL_ABSORPTION | 1.204 | 2.874 × 10−3 |
| REACTOME_MET_RECEPTOR_ACTIVATION | 1.194 | 3.430 × 10−3 |
| REACTOME_MULTIFUNCTIONAL_ANION_EXCHANGERS | 1.188 | 3.152 × 10−3 |
| REACTOME_AMINO_ACID_CONJUGATION | 1.176 | 5.263 × 10−3 |
| REACTOME_CONJUGATION_OF_BENZOATE_WITH_GLYCINE | 1.176 | 5.263 × 10−3 |