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Circulating hybrid cells (CHCs) correlate with residual nodal disease in the patients with esophageal adenocarcinoma after neoadjuvant therapy. The patients without lymph node metastasis on pathology had lower CHC levels than the patients with at least one positive node (P = 0.026). The patient with the highest CHC level in the node-negative group had extra-nodal tumor deposits identified on pathology, which may have prognostic implications similar to node positivity.
