TABLE 2.
HMR 3004 PAE parameters
| Strain | Erythromycin A susceptibilitya | MIC (mg/liter) | Range of PAEsb (h) | PAEmax (h)c | E50 (mg · h/liter)c | Corrected r2c |
|---|---|---|---|---|---|---|
| S. aureus | ||||||
| ATCC 25923 | S | 0.063 | 0–3.6 | 3.3 | 0.16 | 0.990 |
| 3B | S | 0.125 | 0.3–3.0 | 3.1 | 0.54 | 0.995 |
| 2A | Ri | 0.063 | 0.3–3.0 | 2.7 | 0.15 | 0.951 |
| 2E | Ri | 0.063 | 0.2–3.6 | 4.5 | 1.03 | 0.928 |
| S. pyogenes | ||||||
| ATCC 19615 | S | 0.016 | 0.3–3.7 | 3.8 | 0.06 | 0.981 |
| 3A | S | 0.031 | 0.6–3.7 | 4.0 | 0.16 | 0.976 |
| 2A | Rc | 0.125 | 0.5–3.8 | 3.9 | 0.25 | 0.931 |
| 2B | Rc | 0.125 | 1.0–4.2 | 4.9 | 0.47 | 0.960 |
| S. pneumoniae | ||||||
| ATCC 49619 | S | 0.008 | 0.3–4.0 | 4.3 | 0.04 | 0.988 |
| 3Ad | S | 0.016 | 0.2–3.5 | 3.7 | 0.05 | 0.993 |
| 4A | Rc | 0.016 | 0.3–3.5 | 3.9 | 0.09 | 0.987 |
| 4Bd | Rc | 0.016 | 0.4–4.0 | 4.4 | 0.09 | 0.992 |
a
S, susceptible; Rc, constitutively resistant; Ri, inducibly resistant.
b
0.5 to 64 times the MIC.
c
PAEmax, n, and E50 were estimated by nonlinear least-squares regression, and corrected r2 shows the degree of fit with the experimental data, using Systat (version 8.0).
d
These strains also had reduced susceptibility or resistance to penicillin.