TABLE 3.

Comparison of MICs and PAE parameters between erythromycin A-resistant and susceptible strains

Agent and species	Erythromycin A susceptibility	Geometric mean MIC (mg/liter)	R/S ratio for MICa	Arithmetic mean PAEmax (h)	S/R ratio for PAEmaxb	Geometric mean E50 (mg · h/liter)	R/S ratio for E50c	E50/MIC ratiod
Telithromycin
S. aureus	S	0.099	0.89	3.9	0.96	0.50	3.91	5.1
	R	0.088		4.0		1.97		22.3
S. pyogenes	S	0.022	22.63	8.9	2.52	0.06	3.88	2.7
	R	0.5		3.5		0.23		0.5
S. pneumoniae	S	0.011	8.00	9.7	1.51	0.10	1.58	9.0
	R	0.088		6.4		0.16		1.8
HMR 3004
S. aureus	S	0.088	0.71	3.2	0.89	0.38	2.35	4.3
	R	0.063		3.6		0.89		14.2
S. pyogenes	S	0.022	5.66	3.9	0.89	0.78	0.80	35.2
	R	0.125		4.4		0.62		5.0
S. pneumoniae	S	0.011	1.41	4.0	0.98	0.90	0.92	81.2
	R	0.016		4.1		0.82		53.0

^aRatio of geometric mean MICs of erythromycin A-resistant to -susceptible strains. 

^bRatio of geometric mean PAE_maxs of erythromycin A-susceptible to resistant strains. 

^cRatio of geometric mean E₅₀s of erythromycin A-resistant to -susceptible strains. 

^dRatio of geometric mean E₅₀s to geometric mean MICs.