Table 3.
Pregnancy outcomes in women with and without endometriosis
| Primary outcome following first embryo transfer | No endometriosis n = 248 transfers |
Endometriosis n = 132 transfers |
||
|---|---|---|---|---|
| Number of embryos transferred | 1.4 ± 0.72 | 1.3 ± 0.74 | 1.4 ± 0.68 | 0.62a1 |
| Embryo transfer day | 0.35d | |||
| Day 3 embryo transfers | 53 (13.9) | 38 (15.3) | 15 (11.4) | |
| Day 5 embryo transfers | 327 (86.1) | 210 (84.6) | 117 (88.6) | |
| Implantation rate | 0.50 [0.00, 1.00] | 0.50 [0.00, 1.00] | 0.50 [0.00, 1.00] | 0.56b |
| Clinical pregnancy | 249 (65.5) | 165 (66.5) | 84 (63.6) | 0.57c |
| Live birth | 216 (57.8) | 142 (58.7) | 74 (56.1) | 0.62c |
| Miscarriage | 26 (10.4) | 17 (10.3) | 9 (10.7) | 0.92c |
| Multiples | 41 (18.9) | 30 (21.1) | 11 (14.8) | 0.36d |
| Cumulative outcomes (all embryo transfers resulting from retrieval) |
No endometriosis n = 387 transfers |
Endometriosis n = 194 transfers |
||
| Mean number of embryo transfers resulting from each retrieval | 1.3 ± 0.91 | 1.4 ± 0.95 | 1.3 ± 0.85 | 0.65a1 |
| Mean number of embryos transferred at each transfer | 1.5 ± 0.5 | 1.5 ± 0.5 | 1.5 ± 0.48 | 0.59a1 |
| Clinical pregnancy | 295 (77.6) | 199 (80.2) | 96 (72.7) | 0.094c |
| Live birth | 269 (70.8) | 181 (73.0) | 88 (66.7) | 0.20c |
| Outcomes by transfer type (fresh versus frozen) | ||||
| Fresh embryo transfer | No endometriosis | Endometriosis | ||
| Day 3 transfers | n = 53 | n = 38 | n = 15 | |
| Implantation rate | 0.0 [0.0, 0.5] | 0.0 [0.0, 1.0] | 0.50 [0.0, 0.5] | 0.27b |
| Clinical pregnancy | 21 (39.6) | 14 (36.8) | 7 (46.6) | 0.55d |
| Live birth | 139 (52.4) | 12 (31.6) | 6 (40.0) | 0.75d |
| Day 5 transfers | n = 212 | n = 133 | n = 79 | |
| Implantation rate | 0.5 [0.0, 1.0] | 0.5 [0.0, 1.0] | 1.0 [0.5, 1.0] | 0.11b |
| Clinical pregnancy | 152 (71.7) | 102 (76.7) | 50 (63.3) | 0.04d |
| Live birth | 127 (59.9) | 83 (62.4) | 44 (55.6) | 0.38d |
| Frozen embryo transfer | n = 115 | n = 77 | n = 38 | |
| Implantation rate | 1.0 [0.0, 1.0] | 1.0 [0.0, 1.0] | 1.0 [0.0, 1.0] | 0.64d |
| Clinical pregnancy | 79 (68.6) | 52 (67.5) | 27 (71.0) | 0.83d |
| Live birth | 71 (61.7) | 47 (61.0) | 24 (63.1) | 0.91d |
Statistics presented as mean ± SD, median [P25, P75], N (column %). p values: a1 = t test, a2 = Satterthwaite t test, b = Wilcoxon rank sum test, c = Pearson’s chi-square test, d = Fisher’s exact test