Table 3.

Lipophilicity, drug-likeness, medicinal chemistry, and pharmacokinetics based on ADMET (for absorption, distribution, metabolism, excretion, and toxicity) properties of the major ZO identified compounds

Entry/compound name		1	2	3	4	5
		Caffeic acid	Ferulic acid	Rosmarinic acid	Amentoflavone	Syringic acid
Lipophilicity/Drug-likeness	Molecular weight	180.16	194.18	360.31	538.46	198.17
	TPSA (Å2)	77.76	66.76	144.52	181.80	75.99
	Consensus Log Po/w	0.93	1.36	1.58	3.62	0.99
	Lipinskiˈs Rule	Yes	Yes	Yes	No	Yes
	Bioavailability Score	0.56	0.85	0.56	0.17	0.56
Pharmacokinetics/Medicinal Chemistry	GI absorption	High	High	Low	Low	High
	BBB permeant	No	Yes	No	No	No
	P-gp substrate	No	No	No	No	No
	CYP1A2 inhibitor	No	No	No	No	No
	CYP2C19 inhibitor	No	No	No	No	No
	CYP2C9 inhibitor	No	No	No	No	No
	CYP2D6 inhibitor	No	No	No	No	No
	CYP3A4 inhibitor	No	No	No	No	No
	Log Kp (cm/s)	− 6.58	− 6.41	− 6.82	− 6.01	− 6.77
	Leadlikeness	No	No	No	No	No
	Synthetic accessibility	1.81	1.93	3.38	4.27	1.70