TABLE 1.
Results of prophylaxis in animals challenged with S. oralis or S. aureus (MRSA)
| Antibiotic |
S. oralis
|
S. aureusa
|
||||
|---|---|---|---|---|---|---|
| MIC/MBC (μg/ml) | No. of sterile vegetation cultures/total no. (%) | Log10 CFU/g of heart tissue (mean ± SD) | MIC/MBC (μg/ml) | No. of sterile vegetation cultures/total no. (%) | Log10 CFU/g of heart tissue (mean ± SD) | |
| None | – | 1/10 (10) | 8.0 ± 1.0 | – | 1/17 (6) | 9.2 ± 1.4 |
| AMP | <0.12/0.5 | 13/18 (72)b | 6.1 ± 1.9 | NS | NS | NS |
| VAN | 0.5/1 | NSc | NS | 1/1 | 17/18 (94)b | 6.8e |
| AZM | <0.06/2 | 16/17 (94)bd | 5.43e | 1/64 | 10/17 (59)bf | 4.7 ± 1.5 |
a
Oxacillin MIC and MBC = 64 and 128 μg/ml, respectively; erythromycin MIC = 2 μg/ml.
b
Significantly different from the value obtained for the control group (P < 0.001).
c
NS, not studied.
d
Not significantly different from the value obtained for the group treated with AMP (P = 0.177).
e
Value for the one animal in each group in which prophylaxis failed.
f
Significantly different from the value obtained for the group treated with VAN (P = 0.018).