TABLE 2.
Levels of AMP, VAN, and AZM in serum or heart valve tissue
| Antibiotic (dose, administration routea) | Level (μg/ml mean ± SD) in serum at the following time (h) postdosing:
|
Level (μg/g) in heart valve tissue at the following time (h) postdosing:
|
||||||
|---|---|---|---|---|---|---|---|---|
| 0.5 | 1 | 2 | 4 | 2 | 6 | 12 | 24 | |
| AZMb (50 mg/kg, p.o.) | <0.3 | 0.91 ± 0.25 | 0.51 ± 0.15 | <0.3 | 1.4 | 3.5 | 2.8 | 2.5 |
| AMPc (40 mg/kg, i.v.) | 13.5 ± 6.8 | 7.3 ± 3.2 | 1.2 ± 0.5 | NDe | ||||
| VANd (30 mg/kg, i.v.) | 71.5 ± 13.7 | 51.1 ± 7.1 | 37.6 ± 9.9 | ND | ||||
a
Abbreviations: p.o., per os; i.v., intravenous.
b
Lower limit of detection of AZM in serum (agar well bioassay), 0.3 μg/ml. AZM was not detected in heart valve tissue 1 h after the dose was given.
c
Lower limit of detection (agar well bioassay), 0.1 μg/ml.
d
Lower limit of detection (fluorescence polarization immunoassay), 0.6 μg/ml.
e
ND, not done.