Table 2:

Example of the complex immunosuppressive, anti-inflammatory, and adjunctive therapy used in pig-to-baboon kidney transplantation experiments during the past several years.

Agent	Dose (duration)
Induction
Thymoglobulin (ATG) (Genzyme, Cambridge, MA)	10 mg/kg i.v. (day −3) (to reduce the CD3+T cell count to <500/mm3)
Anti-CD20mAb (rituximab) (Genentech, South San Francisco, CA)	10 mg/kg i.v. (day −2)
Cobra venom factor (CVF) (Complement Technology, Tyler, TX) OR C1-esterase inhibitor (Berinert, CSL Behring, King of Prussia, PA)	100 U/kg (days −1 and 0) 17.5 U/kg i.v. (days 0, 1, 7 and 14)
Maintenance
Anti-CD40 monoclonal antibody (mAb) (2C10R4, a chimeric rhesus IgG4) (NIH NHP Resource Center, Boston, MA)	50 mg/kg (days −1, 0, 4, 7, 14, and weekly)
Rapamycin (Rapa) (LC Laboratories, Woburn, MA)	0.01–0.04 mg/kg i.m. ×2/d (target trough 6–10 ng/ml), beginning on day −4.
Methylprednisolone (Astellas, Deerfield, IL)	5 mg/kg/d on day 0, tapering to 0.125 mg/kg/d by day 7.
Anti-inflammatory
Etanercept (TNF-α antagonist) (Amgen, Thousand Oaks, CA)	1 mg/kg (day 0), 0.5 mg/kg i.v. (days 3, 7, 10)
Adjunctive
Triiodothyronine (levothyroxine) (Xgen, Big Flats, NY, USA) Aspirin (Bayer, Deland, FL)	4μg i.v. x2/day on days 0–5. 40 mg p.o. (alternate days), beginning on day 4.
Low molecular weight heparin (LMWH) (Eisai, Woodcliff Lake, NJ)	700 IU/d s.c., beginning of day 1.
Famotidine (APP Pharmaceuticals, Schaumburg, IL)	0.25 mg/kg/d ×2 (days −7 to 14)
Erythropoietin (Amgen)	500 U i.v. x2-3 weekly, beginning on day −4
Ganciclovir (Genentech)	5 mg/kg/d i.v., from day −4 to day 14 and when the baboon is sedated for blood draws (x2 weekly).
Valganciclovir (Genentech)	15 mg/kg/d p.o., beginning on day 15
Sulfamethoxazole and trimethoprim (Teva, North Wales, PA)	10 mg/kg i.v. daily, on days 4–14
Sulfamethoxazole and trimethoprim oral suspension (Akorn, Lake Forest, IL)	75 mg/m2 p.o x2/day. x3 weekly, beginning on day 15.