FIG. 1.

Effect of antiviral treatments on WHV replication in chronic WHV carrier woodchucks. Horizontal bars denote the treatment period. Values for individual animals in each treatment group are displayed in the top 12 panels. Mean values for all of the experimental groups are compared in the bottom two panels (vertical lines denote standard deviations). WHVge, WHV genomic equivalents (virion or WHV DNA-containing virus particles); WHV RI, hepatic WHV DNA RI. Levels of hepatic cellular DNA were quantified by hybridization to a commercial β-actin gene probe (Oncor, Inc., Gaithersburg, Md.) by Southern or dot blot hybridization techniques as described in the text.