. Author manuscript; available in PMC: 2023 Jul 1.

Published in final edited form as: Drug Deliv Transl Res. 2021 Oct 11;12(7):1684–1696. doi: 10.1007/s13346-021-01065-7

Table 2.

Pharmacokinetic parameters of PD98059 in plasma after IV administration of PD98059 solution to healthy mice.

Non compartment model		One-compartment model		Two-compartment model
Parameters	PD98059 solution	Parameters	PD98059 solution	parameters	PD98059 solution
K (min ⁻¹)	0.0022	K (min ⁻¹)	0.033	A (μg/mL)	2.65
T_1/2 (min)	314.87	T_1/2 (min)	20.91	α (min ⁻¹)	0.076
C₀ (μg/mL)	2.91	C₀ (μg/mL)	2.63	B (μg/mL)	0.49
AUC_0-t (μg x min/mL)	175.72	AUC_0-t (μg x min/mL)	79.61	β (min ⁻¹)	0.0016
AUC_0-inf (μg x min/mL)	320.68	AUC_0-inf (μg x min/mL)	79.61	K₁₀ (min ⁻¹)	0.0092
AUMC_0-inf (μg x min²/mL)	140,206.69	AUMC_0-inf (μg x min²/mL)	2,402.29	K₁₂ (min ⁻¹)	0.055
MRT_0-inf (min)	437.20	MRT_0-inf (min)	30.17	K₂₁ (min ⁻¹)	0.013
V (mL)	141.65	V (mL)	37.90	T_1/2(α) (min)	9.06
Cl (mL/min)	0.31	Cl (mL/min)	1.25	T_1/2(β) (min)	427.63
V_ss (mL)	136.33	V_ss	37.90	C₀ (μg/mL)	3.15
		R²	0.9715	V (mL)	31.72
				Cl (mL/min)	0.29
				AUC_0-t (μg x min/mL)	170.01
				AUC_0-inf (μg x min/mL)	340.78
				AUMC_0-inf (μg x min²/mL)	189,279.12
				MRT_0-inf (min)	555.42
				V_ss (mL)	162.98
				R²	0.9964

K: elimination rate constant, T_1/2: plasma half-life, C₀: plasma concentration at time 0, AUC: area under the plasma concentration-time curve, AUMC: area under the moment curve, MRT: mean residence time, V: volume of distribution, Cl: clearance and V_ss: Volume of distribution at steady state