Table 3.
Pharmacokinetic parameters of PD98059 in plasma after IV administration of PD98059-PGM NPs to healthy mice.
| Non compartment model | One-compartment model | Two-compartment model | |||
|---|---|---|---|---|---|
| Parameters | PD98059-PGM NPs |
Parameters | PD98059-PGM NPs |
Parameters | PD98059-PGM NPs |
| K (min −1) | 0.0014 | K (min −1) | 0.038 | A (μg/mL) | 3.13 |
| T1/2 (min) | 466.75 | T1/2 (min) | 17.80 | α (min −1) | 0.087 |
| C0 (μg/mL) | 3.26 | C0 (μg/mL) | 3.04 | B (μg/mL) | 0.52 |
| AUC0-t (μg x min/mL) |
209.72 | AUC0-t (μg x min/mL) |
78.23 | β (min −1) | 0.00093 |
| AUC0-inf (μg x min/mL) |
445.54 | AUC0-inf (μg x min/mL) |
78.23 | K10 (min −1) | 0.0061 |
| AUMC0-inf (μg x min2/mL) |
271,559.48 | AUMC0-inf (μg x min2/mL) |
2,009.44 | K12 (min −1) | 0.068 |
| MRT0-inf (min) | 609.49 | MRT0-inf (min) | 25.68 | K21 (min −1) | 0.013 |
| V (mL) | 151.14 | V (mL) | 32.82 | T1/2(α) (min) | 7.95 |
| Cl (mL/min) | 0.22 | Cl (mL/min) | 1.27 | T1/2(β) (min) | 745.09 |
| Vss (mL) | 136.79 | Vss (mL) | 32.82 | C0 (μg/mL) | 3.66 |
| R2 | 0.9699 | V (mL) | 27.28 | ||
| Cl (mL/min) | 0.16 | ||||
| AUC0-t (μg x min/mL) |
198.05 | ||||
| AUC0-inf (μg x min/mL) |
605.49 | ||||
| AUMC0-inf (μg x min2/mL) |
612,620.73 | ||||
| MRT0-inf (min) | 1,011.76 | ||||
| Vss (mL) | 167.09 | ||||
| R2 | 0.9991 | ||||
K: elimination rate constant, T1/2: plasma half-life, C0: plasma concentration at time 0, AUC: area under the plasma concentration-time curve, AUMC: area under the moment curve, MRT: mean residence time, V: volume of distribution, Cl: clearance and Vss: Volume of distribution at steady state.