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Pharmacokinetic parameter (AUC) of PD98059 in organs after IV administration of free drug solution and PD98059-PGM NPs to healthy mice.
| Organs | AUC0-6 (μg x min/mL) | |
|---|---|---|
| PD98059 solution | PD98059-PGM NPs | |
| Brain | 334.25 | 1,160.83 |
| Heart | 160.37 | 212.05 |
| Lung | 459.51 | 561.27 |
| Pancreas | 177.37 | 233.56 |
| Spleen | 129.72 | 160.68 |
| Kidney | 301.47 | 555.96 |
| Liver | 125.38 | 197.93 |
| Muscle | 129.86 | 153.86 |
