TABLE 3.
Comparison of subdivided LC-R/C cases.
| All LC-R/C | noATI | ATI | Constipative1 | Crystalline | Constipative2 | p-value* | p-value, post hoc | |
| Total number of biopsies (%) | 81 | 9 (11.1%) | 55 (67.9%) | 3 (3.7%) | 8 (9.9%) | 6 (7.4%) | ||
| Clinical parameters: | ||||||||
| Age at biopsy (years), mean (range) | 69.3 (35.4–87.4) | 61.9 (48.8–77.7) | 69.1 (35.4–87.4) | 76 (68.9–80.5) | 71.4 (47.1–85) | 78.3 (60.7–84.3) | 0.156 | |
| Sex (f/m) | 36/45 | 3/6 | 25/30 | 0/3 | 4/4 | 4/2 | 0.383 | |
| Diabetes mellitus (yes/no) | 15/47 | 1/7 | 10/31 | 1/1 | 1/5 | 2/3 | 0.701 | |
| Hypertension (yes/no) | 38/23 | 3/4 | 25/16 | 2/0 | 4/2 | 4/1 | 0.544 | |
| GFR ml/min | 13.1 (3–109), 74 | 69.1 (29.9–109), 8 | 10.2 (3–70), 49 | 22.1 (10.1–24), 3 | 30 (3.8–85.2), 8 | 18 (9.6–38.3), 6 | <0.001 | noATI-ATI < 0.001 |
| Serum creatinine mg/dl | 4.3 (0.5–18.3), 74 | 1.14 (0.5–2.1), 8 | 4.7 (1–18.3), 49 | 2.7 (2.6–5.5), 3 | 2.14 (0.8–10.4), 8 | 3.8 (1.3–4.4), 6 | <0.001 | noATI–ATI < 0.001 |
| Proteinuria score | 3 (0–4), 68 | 3 (2–4), 8 | 3 (0–4), 44 | 3.5 (3–4), 2 | 2.5 (0–4), 8 | 4 (4–4), 6 | 0.064 | |
| Nephrotic syndrome (yes/no) | 6/39 | 1/5 | 1/28 | 0/1 | 0/5 | 4/0 | <0.001 | constipative 2 < 0.001 |
| Hematuria score | 1 (0-3), 53 | 1 (0-1), 7 | 1 (0-3), 35 | 1 (1-1), 2 | 1 (0-3), 6 | 1 (0–2), 3 | 0.630 | |
| History of No/MG/MM/BNHL | 9/39/33/0 | 0/4/5/0 | 6/27/22/0 | 0/1/2/0 | 0/5/3/0 | 3/2/1/0 | 0.110 | |
| Unknown/κ/λ/κ &λ | 36/18/26/1 | 1/1/7/0 | 27/11/17/0 | 1/2/0/0 | 2/4/1/1 | 5/0/1/0 | κ vs λ: | |
| 0.51 | ||||||||
| Biopsy findings: | ||||||||
| Glomerulosclerosis% | 8.7 (0–83.9), 79 | 13.8 (0–41.8), 9 | 8.5 (0–83.9), 54 | 6.3 (0–56), 3 | 6.1 (0–38.1), 8 | 33.3 (0–50), 5 | 0.430 | |
| IF/TA% | 20 (0–80), 80 | 5 (0–30), 9 | 20 (0–80), 55 | 15 (15–30), 3 | 20 (0–80), 8 | 25 (15–60), 5 | 0.092 | |
| ATI score | 3 (0–4), 80 | 1 (0–1), 9 | 4 (2–4), 55 | 4 (2–4), 3 | 3 (0–4), 8 | 3 (1–4), 5 | <0.001 | noATI-ATI < 0.001 |
| noATI-constipative 1 0.042 | ||||||||
| LC restriction κ/λ (IHC) | 30/48 | 1/8 | 21/34 | 3/0 | 4/1 | 1/5 | 0.014 | n.s. |
| Infiltration: no/MM/BNHL | 75/6/0 | 9/0/0 | 49/6/0 | 3/0/0 | 8/0/0 | 6/0/0 | 0.547 | |
| Coexisting LC associated renal diagnoses | 42 Cast | 2 AL amyloidosis | 35 Cast | 2 Cast | 5 Cast | 4 AL amyloidosis | AL <0.001 | Cast-NP: |
| 4 Cast and MM infiltrate | 4 Cast and MM infiltrate | 1 AL amyloidosis | Cast <0.001 | ATI <0.001 | ||||
| 1 Cast and MIDD | 1 Cast and MIDD | MIDD | noATI 0.001 | |||||
| 1 susp. of Cast | 1 susp. of Cast | 0.914 | Constipative 2 0.03 | |||||
| 1 MIDD | 1 MIDD | AL: | ||||||
| 2 MM infiltrate | 2 MM infiltrate | ATI <0.001 | ||||||
| 7 AL amyloidosis | Constipative2 <0.001 | |||||||