FIGURE 6.

C‐Jun inhibits erastin‐induced ferroptosis via the NRF2/HO‐1 pathway. (A, C) The expression of the c‐Jun protein in RSC 96 and pSCs after siRNA transfection by Western blot. (B, D) Densitometric analysis of c‐Jun protein. (E, G) The expression of PTGS2, NRF2, c‐Jun, HO‐1 and GPX4 proteins with or without siRNA in c‐Jun overexpression and control RSC 96 and pSCs. (F, H) Densitometric analysis of G PTGS2, NRF2, c‐Jun, HO‐1 and GPX4 proteins. Data are presented as mean ± SD, and one‐way ANOVA was performed for statistical differences between groups. All experiments were performed at least 3 times independently, *p < 0.05, **p < 0.01, compared to the control group