Table 2.

Hazard ratios of mental illnesses from the multivariable Cox proportional hazards model in the end-stage kidney disease cohort (n = 70,079)

Psychiatric disorder	Parameter		HR (95% CI)	p-value
Depression	KRT	HD	2.19 (1.95–2.46)	<0.001
		PD	1.97 (1.73–2.26)	<0.001
		KT	Ref
	Age group (yr)	18–39	Ref
		40–59	1.17 (1.09–1.26)	<0.001
		≥60	1.27 (1.18–1.36)	<0.001
	Male sex		1.17 (1.13–1.22)	<0.001
Anxiety	KRT	HD	1.64 (1.50–1.80)	<0.001
		PD	1.22 (1.09–1.35)	0.001
		KT	Ref
	Age group (yr)	18–39	Ref
		40–59	1.11 (1.04–1.18)	0.002
		≥60	1.04 (0.98–1.11)	0.23
	Male sex		1.20 (1.16–1.24)	<0.001
Somatoform/conversion disorder	KRT	HD	0.96 (0.70–1.32)	0.80
		PD	0.60 (0.38–0.97)	0.04
		KT	Ref
	Age group (yr)	18–39	Ref
		40–59	0.98 (0.76–1.26)	0.87
		≥60	0.71 (0.54–0.92)	0.01
	Male sex		1.07 (0.91–1.26)	0.42
Stress reaction/adjustment disorder	KRT	HD	1.67 (1.29–2.15)	<0.001
		PD	0.99 (0.72–1.39)	0.98
		KT	Ref
	Age group (yr)	18–39	Ref
		40–59	0.99 (0.76–1.06)	0.19
		≥60	0.91 (0.77–1.08)	0.28
	Male sex		1.08 (0.98–1.19)	0.11
Substance abuse disorder	KRT	HD	2.40 (1.31–4.38)	0.004
		PD	1.84 (0.90–3.77)	0.10
		KT	Ref
	Age group (yr)	18–39	Ref
		40–59	1.22 (0.86–1.73)	0.28
		≥60	0.83 (0.57–1.19)	0.31
	Male sex		3.30 (2.58–4.37)	<0.001

HR, hazard ratio; CI, confidence interval; HD, hemodialysis; KT, kidney transplant; KRT, kidney replacement therapy; PD, peritoneal dialysis; Ref, reference group.