TABLE 1.
Univariate and multivariate regression analyses for risk factors of having HbA1c ≥39 mmol·mol−1 at the time of tuberculosis (TB) diagnosis
Risk factor | Crude analysis | Multivariate analysis # | ||
OR (95% CI) | p-value | OR (95% CI) | p-value | |
Age | ||||
≤40 years | 1 (ref.) | 1 (ref.) | ||
>40 years | 6.3 (2.2–22.8) | 0.002 | 5.6 (1.9–20.9) | 0.004 |
Sex | ||||
Female | 1 (ref.) | 1 (ref.) | ||
Male | 5.4 (2.0–17.2) | 0.002 | 4.6 (1.7–14.9) | 0.006 |
Substance use | ||||
No history of excessive alcohol intake | 1 (ref.) | 1 (ref.) | ||
History of excessive alcohol intake | 2.4 (1.0–5.6) | 0.044 | 2.0 (1.0–5.1) | 0.138 |
No history of smoking | 1 (ref.) | 1 (ref.) | ||
Previous or current smoker | 1.7 (0.7–4.4) | 0.271 | 0.6 (0.2–1.9) | 0.396 |
No history of drug use | 1 (ref.) | 1 (ref.) | ||
History of drug use | 1.0 (0.4–2.4) | 0.994 | 1.1 (0.4–3.1) | 0.862 |
Region of origin | ||||
Denmark | 1 (ref.) | 1 (ref.) | ||
Greenland | 1.9 (0.6–5.6) | 0.243 | 3.6 (1.0–14.6) | 0.056 |
Immigrant¶ | 1.3 (0.6–3.2) | 0.495 | 5.9 (1.7–24.2) | 0.009 |
Disease presentation | ||||
Pulmonary TB | 1 (ref.) | 1 (ref.) | ||
Extra-pulmonary TB | 0.2 (0.0–1.1) | 0.123 | 0.3 (0.0–1.7) | 0.234 |
Disseminated TB+ | 7.5 (1.6–54.0) | 0.017 | 10.6 (1.8–91.5) | 0.013 |
No cavitations§ | 1 (ref.) | 1 (ref.) | ||
Cavitations§ | 4.8 (1.8–13.3) | 0.002 | 5.3 (1.8–17.2) | 0.003 |
#: adjusted for age and sex, not including the measured risk factor; ¶: all patients not born in Denmark or Greenland; +: more than one TB location, including military TB; §: in patients with pulmonary TB.