FIGURE 1.

a) Main outcomes after each procedure and combined outcomes. b) Computed tomography scan and c) perfusion tomoscintigraphy showing the example of a patient with an extremely heterogeneous emphysema who experienced dramatic improvements after both interventions: forced expiratory volume in 1 s (FEV₁) increase by 73% after a first right lower lobe EBV treatment (460 mL to 800 mL) and 74% more after a subsequent left lower lobe treatment (800 mL to 1380 mL), after an overall 2950 mL residual volume (RV) decrease (7840 to 4890 mL). d) Changes in the main parameters: RV, FEV₁, 6-min walking distance (6MWD) and BODE (body mass index, obstruction (FEV₁), dyspnoea (modified Medical Research Council dyspnoea score (mMRC)), exercise capacity (6MWD)) score (median) after the first procedure (T1) and after contralateral treatment (T2). TLVR: target lung volume reduction; NA: not applicable.