Table 5.

Berberine targets epigenetic enzymes for cancer therapeutics.

Compound	Targets	Tumor types	Ref.
Berberine	EZH2/H3K27me3	Osteosarcoma	(134)
Berberine	Global histone H3/H4 acetylation	Lung cancer	(135)
Berberine	DNMTs	Gastric cancer	(136)
Berberine	DNMT1/DNMT3B	MM	(137)