Table 1.

Incidence rate ratios of the first recorded cases of anxiety and depressive disorders stratified by sex, age group, and MEDEA Deprivation Index according to the study period

	Incidence rate ratio (95% CI) for each time period
	Anxiety disorders (n=196 933)*				Depressive disorders (n=40 020)*
	Lockdown period (March–June 2020)	Postlockdown period 1 (July–September 2020)	Postlockdown period 2 (October–December 2020)	Postlockdown period 3 (January–March 2021)	Lockdown period (March–June 2020)	Postlockdown period 1 (July–September 2020)	Postlockdown period 2 (October–December 2020)	Postlockdown period 3 (January–March 2021)
Overall	1.19 (1.17 to 1.22)	0.94 (0.92 to 0.96)	1.00 (0.98 to 1.03)	1.00 (0.98 to 1.03)	0.64 (0.61 to 0.67)	0.94 (0.89 to 0.99)	0.95 (0.90 to 1.00)	0.97 (0.93 to 1.02)
Sex
Women	1.17 (1.14 to 1.20)	0.95 (0.92 to 0.97)	1.05 (1.02 to 1.08)	1.01 (0.98 to 1.04)	0.64 (0.61 to 0.68)	0.91 (0.85 to 0.97)	0.97 (0.91 to 1.04)	0.95 (0.89 to 1.01)
Men	1.24 (1.20 to 1.27)	0.94 (0.90 to 0.97)	0.94 (0.91 to 0.98)	1.00 (0.96 to 1.03)	0.64 (0.59 to 0.69)	1.00 (0.92 to 1.08)	0.92 (0.84 to 1.00)	1.01 (0.93 to 1.09)
Sex: women
Age group (years)
18–34	1.06 (1.01 to 1.11)	0.94 (0.89 to 1.00)	1.14 (1.08 to 1.20)	1.14 (1.08 to 1.19)	0.60 (0.51 to 0.71)	1.01 (0.84 to 1.21)	1.17 (0.99 to 1.38)	1.12 (0.96 to 1.31)
35–64	1.25 (1.21 to 1.29)	0.95 (0.91 to 0.99)	1.02 (0.98 to 1.07)	0.97 (0.93 to 1.00)	0.70 (0.64 to 0.76)	0.93 (0.84 to 1.02)	0.99 (0.90 to 1.09)	0.92 (0.85 to 1.01)
>65	1.10 (1.04 to 1.17)	0.94 (0.87 to 1.01)	0.97 (0.91 to 1.04)	0.94 (0.88 to 1.01)	0.61 (0.56 to 0.67)	0.88 (0.79 to 0.97)	0.90 (0.81 to 0.99)	0.94 (0.85 to 1.03)
Sex: men
Age group (years)
18–34	1.12 (1.06 to 1.18)	0.97 (0.91 to 1.04)	0.99 (0.92 to 1.06)	1.07 (1.00 to 1.14)	0.58 (0.47 to 0.71)	1.00 (0.81 to 1.23)	0.99 (0.81 to 1.22)	1.09 (0.90 to 1.30)
35–64	1.27 (1.22 to 1.32)	0.93 (0.88 to 0.97)	0.92 (0.88 to 0.97)	0.98 (0.94 to 1.03)	0.64 (0.57 to 0.71)	0.94 (0.83 to 1.06)	0.89 (0.80 to 1.01)	1.03 (0.93 to 1.15)
>65	1.38 (1.27 to 1.49)	0.87 (0.78 to 0.97)	0.90 (0.81 to 1.00)	0.85 (0.76 to 0.94)	0.69 (0.61 to 0.78)	1.11 (0.96 to 1.27)	0.95 (0.82 to 1.09)	0.95 (0.83 to 1.10)
MEDEA Deprivation Index
First, least deprived	1.11 (1.05 to 1.16)	0.94 (0.88 to 1.01)	1.04 (0.98 to 1.11)	0.94 (0.89 to 1.00)	0.70 (0.62 to 0.79)	0.94 (0.81 to 1.08)	0.88 (0.76 to 1.00)	1.07 (0.94 to 1.22)
Second	1.22 (1.17 to 1.28)	0.90 (0.84 to 0.95)	0.96 (0.90 to 1.02)	1.00 (0.95 to 1.06)	0.65 (0.57 to 0.73)	0.94 (0.81 to 1.08)	0.99 (0.86 to 1.13)	0.92 (0.81 to 1.04)
Third	1.19 (1.14 to 1.25)	0.94 (0.88 to 1.00)	1.00 (0.94 to 1.06)	0.96 (0.91 to 1.02)	0.67 (0.59 to 0.75)	0.89 (0.77 to 1.02)	1.05 (0.92 to 1.21)	0.97 (0.85 to 1.10)
Fourth	1.21 (1.15 to 1.27)	0.93 (0.87 to 0.99)	0.96 (0.91 to 1.02)	0.98 (0.92 to 1.04)	0.64 (0.56 to 0.72)	1.04 (0.91 to 1.20)	1.10 (0.96 to 1.26)	1.05 (0.92 to 1.19)
Fifth, most deprived	1.19 (1.14 to 1.25)	0.90 (0.85 to 0.96)	0.95 (0.90 to 1.02)	1.01 (0.96 to 1.07)	0.55 (0.48 to 0.62)	1.01 (0.88 to 1.17)	0.90 (0.79 to 1.03)	0.97 (0.85 to 1.10)
Rural	1.18 (1.13 to 1.24)	0.96 (0.90 to 1.02)	1.03 (0.97 to 1.09)	1.03 (0.98 to 1.09)	0.73 (0.65 to 0.81)	1.02 (0.91 to 1.16)	0.98 (0.86 to 1.11)	1.06 (0.94 to 1.19)

Incidence rate ratios were calculated by dividing the incidence rate obtained for each strata during the COVID-19 periods (lockdown and postlockdown periods) by the incidence rate obtained for the same time period in 2018 and 2019.

The MEDEA Deprivation Index is calculated at the census tract level in the urban areas of Catalonia and categorised in quintiles of deprivation.

*Total number of diagnoses from March 2018 to March 2021.

MEDEA, Mortalidad en áreas pequeñas Españolas y Desigualdades Socioeconómicas y Ambientales.