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. 2022 Mar 28;12:861284. doi: 10.3389/fonc.2022.861284

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Copyright © 2022 Yin, Che, Wang, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of the knockdown of GSDME expression on gastric cancer cells. (A). Relative expression levels of GSDME in gastric cancer and adjacent to paracancerous tissues. (B) Expression of GSDME in human gastric cancer cell lines HS-746T and MKN74 and gastric mucosal cells GES-1. (C) Transfection efficiency. (D) Effect of reduced GSDME levels on the proliferation of HS-746T cells. (E) Effect of reduced GSDME levels on the proliferation of MKN74 cells. (F) Promotion of apoptosis after GSDME levels were reduced. (G) Flow apoptosis diagram based on HS-746T cells. (H) Flow apoptosis diagram based on MKN74 cells. *P < 0.05, **P < 0.01, ****P < 0.0001.