Table 1.
Baseline characteristics of cirrhotic participants
| Characteristics | Total (n = 553) | C-cirrhosis (n = 388) | D-cirrhosis (n = 165) | p value |
|---|---|---|---|---|
| Age, years | 54 (45–61) | 53 (45–64) | 54 (44–60) | 0.184 |
| Sex, male | 374 (67.63) | 261 (67.27) | 113 (68.48) | 0.843 |
| Body mass index | 24 (22.2–26.0) | 23.8 (22.0–25.4) | 24 (22.5–26.3) | 0.059 |
| Overweight | 223 (40.33) | 157 (40.46) | 66 (40.0) | 0.999 |
| Etiology | ||||
| HBV | 466 (84.27) | 338 (87.11) | 128 (77.58) | 0.007 |
| HCV | 36 (6.69) | 22 (5.9) | 14 (8.48) | 0.267 |
| Alcoholic | 40 (7.45) | 24 (6.45) | 16 (9.7) | 0.213 |
| NAFLD | 17 (3.07) | 15 (3.87) | 2 (1.21) | 0.113 |
| AIH/PBC/PSC | 13 (2.42) | 9 (2.41) | 4 (2.42) | 0.999 |
| Others | 23 (4.16) | 14 (3.61) | 9 (5.45) | 0.353 |
| Chronic hepatitis B | ||||
| HBeAg positive | 99 (20.54) | 79 (23.58) | 20 (13.61) | 0.014 |
| HBV DNA positive | 122 (22.18) | 87 (22.48) | 35 (21.47) | 0.823 |
| Antiviral therapy | 351 (63.47) | 273 (70.36) | 78 (47.27) | < 0.001 |
| Comorbidities | ||||
| Any | 112 (20.25) | 73 (18.81) | 39 (23.64) | 0.205 |
| Hypertension | 70 (13.97) | 47 (13.82) | 23 (14.29) | 0.891 |
| Diabetes | 54 (10.82) | 35 (10.36) | 19 (11.8) | 0.645 |
| Arrhythmia | 13 (2.78) | 9 (2.69) | 4 (3.03) | 0.765 |
| Asthma | 1 (0.2) | 1 (0.3) | 0 (0) | 0.514 |
| CAD | 10 (2.01) | 6 (1.79) | 4 (2.48) | 0.734 |
| Liver function | ||||
| ALT, U/L | 27.0 (18.0–39.0) | 26.0 (18.0–37.2) | 28.3 (19.9–45) | 0.104 |
| AST, U/L | 27.8 (21.4–39.0) | 27.0 (21.0–35.0) | 31.0 (23.0–55.4) | < 0.001 |
| Albumin, g/L | 45.3 (41.0–48.2) | 45.7 (42.3–48.5) | 43.0 (34.8–47.2) | < 0.001 |
| TBIL, μmol/L | 18.3 (13.7–25.1) | 16.8 (12.8–22.4) | 23.4 (16.0–35.1) | < 0.001 |
| DBIL, μmol/L | 4.4 (2.9–7.5) | 3.8 (2.6–6.2) | 6.7 (3.8–11.5) | < 0.001 |
| GGT, U/L | 30.0 (18.8–55) | 28.0 (19.0–48) | 35.0 (20.7–68.0) | 0.014 |
| ALP, U/L | 77.6 (63.0–98.5) | 75.4 (63.0–92.0) | 89.0 (64.0–113.0) | 0.002 |
| Child–Pugh | < 0.001 | |||
| A | 490 (88.61) | 377 (97.16) | 113 (68.48) | |
| B + C | 63 (11.39) | 11 (2.84) | 52 (31.52) |
Data are displayed as median (interquartile range) and n (%). AIH, autoimmune hepatitis; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, aspartate aminotransferase; CAD, Coronary artery disease; C-cirrhosis, compensated cirrhosis; DBIL, direct bilirubin; D-cirrhosis, decompensated cirrhosis; GGT, γ-glutamyl transpeptidase; HBeAg, hepatitis B e antigen; HBV, hepatitis B virus; HCV, hepatitis C virus; NAFLD, nonalcoholic fatty liver disease; PBC, primary biliary cholangitis; PSC, primary sclerosing cholangitis; TBIL, total bilirubin