TABLE 2.
Genes associated with vitamin B6 metabolism and biological processes in which they are involved
| Vitamin B6 gene | Gene in operon | Biological process | Essentiala |
|---|---|---|---|
| epd | pgk | Glycolysis and gluconeogenesis | Yes |
| fba | Glycolysis and gluconeogenesis | Yes | |
| pdxB | usg | Amino acid biosynthesis | No |
| truA | RNA modification | No | |
| dedA | n.r.b | No | |
| serC | aroA | Aromatic amino acid biosynthesis | Yes |
| pdxA | lptD | Membrane organization/response to stress | Yes |
| surA | Protein folding | No | |
| rmsA | rRNA processing and modification | No | |
| apaG | Response to stress | No | |
| apaH | Response to stress/RNA decapping | No | |
| dxs | xseB | DNA catabolism | No |
| ispA | Isoprenoid biosynthesis | Yes | |
| yajO | Isoprenoid biosynthesis | No | |
| pdxJ | rnc | RNA processing | Yes |
| era | Ribosome biogenesis | Yes | |
| recO | DNA repair/response to stress | No | |
| acpS | Fatty acid biosynthesis | Yes | |
| pdxH | tyrS | Translation | Yes |
| yggS | yggT | Response to stress | No |
| yggU | n.r. | No | |
| rdgB | Nucleotide metabolism | No | |
| hemW | Oxidation-reduction process | No |
a
Essential means that the corresponding knockout strain does not grow in minimal medium without supplementation (https://ecocyc.org/). The essential genes are highlighted in green.
b
n.r., not reported.