Table 4.

Treatment-emergent adverse events

Adverse events	Mavrilimumab* (N=42)	Placebo (N=28)
Patients with ≥1 adverse event	33 (78.6%)	25 (89.3%)
Serious adverse event	2 (4.8%)	3 (10.7%)
Serious adverse event related to study drug	0	0
Adverse event resulting in death	0	0
Adverse event leading to study drug discontinuation	1 (2.4%)	1 (3.6%)
Adverse events by maximum severity†
Mild	18 (42.9%)	13 (46.4%)
Moderate	14 (33.3%)	11 (39.3%)
Severe	1 (2.4%)	1 (3.6%)
Most common adverse events‡
Headache	6 (14.3%)	7 (25.0%)
Nasopharyngitis	5 (11.9%)	3 (10.7%)
Neck pain	4 (9.5%)	2 (7.1%)
Arthralgia	2 (4.8%)	4 (14.3%)
Hypertension	1 (2.4%)	4 (14.3%)
Back pain	3 (7.1%)	3 (10.7%)
Muscle spasms	3 (7.1%)	3 (10.7%)
Upper respiratory tract infection	3 (7.1%)	2 (7.1%)
Constipation	3 (7.1%)	0
Diarrhoea	0	3 (10.7%)
Fall	2 (4.8%)	5 (17.9%)

Data are n (%).

*150 mg subcutaneously every 2 weeks.

†Each patient is represented only with maximum severity.

‡Reported in >2 patients in either treatment group.