FIGURE 3.

Trajectories of human cognition-related traits. Max missing genotype per sample: 0.96. QTL p-value cutoff: 10^–6. (A) Significant decreases in PRS can be seen prior to the Neolithic revolution for all cognition-related traits except fluid intelligence, followed by significant increases in PRS over time. This pattern for cognition-related traits is reversed for unipolar depression. (B) LOESS regression models show that between the Mesolithic and Neolithic, and the post-Neolithic and modern era large changes in PRS can be seen, whereas the difference between Neolithic and post-Neolithic is much smaller. (C) t-tests also show that the changes observed are significantly different to a much larger extent between the pre-Neolithic and Neolithic and between the post-Neolithic and Modern era.