Table 1.
Grouping of Clinicopathological Features According to ICOS Expression Levels
| Characteristic | Levels | Low Expression of ICOS | High Expression of ICOS |
|---|---|---|---|
| n | 267 | 268 | |
| Gender | Female | 126 (23.6%) | 160 (29.9%) |
| Male | 141 (26.4%) | 108 (20.2%) | |
| Race | Asian | 5 (1.1%) | 2 (0.4%) |
| Black or African American | 28 (6%) | 27 (5.8%) | |
| White | 202 (43.2%) | 204 (43.6%) | |
| Age | ≤65 | 140 (27.1%) | 115 (22.3%) |
| >65 | 118 (22.9%) | 143 (27.7%) | |
| T | T1 | 68 (12.8%) | 107 (20.1%) |
| T2 | 155 (29.1%) | 134 (25.2%) | |
| T3 | 31 (5.8%) | 18 (3.4%) | |
| T4 | 12 (2.3%) | 7 (1.3%) | |
| N | N0 | 166 (32%) | 182 (35.1%) |
| N1 | 50 (9.6%) | 45 (8.7%) | |
| N2 | 45 (8.7%) | 29 (5.6%) | |
| N3 | 1 (0.2%) | 1 (0.2%) | |
| M | M0 | 180 (46.6%) | 181 (46.9%) |
| M1 | 13 (3.4%) | 12 (3.1%) | |
| Stage | Stage I | 132 (25%) | 162 (30.7%) |
| Stage II | 65 (12.3%) | 58 (11%) | |
| Stage III | 52 (9.9%) | 32 (6.1%) | |
| Stage IV | 13 (2.5%) | 13 (2.5%) | |
| Primary therapy outcome | PD | 46 (10.3%) | 25 (5.6%) |
| SD | 19 (4.3%) | 18 (4%) | |
| PR | 4 (0.9%) | 2 (0.4%) | |
| CR | 151 (33.9%) | 181 (40.6%) | |
| Residual tumor | R0 | 181 (48.7%) | 174 (46.8%) |
| R1 | 8 (2.2%) | 5 (1.3%) | |
| R2 | 1 (0.3%) | 3 (0.8%) | |
| Years of smoking | <40 | 93 (25.2%) | 95 (25.7%) |
| ≥40 | 90 (24.4%) | 91 (24.7%) | |
| Smoker | No | 35 (6.7%) | 40 (7.7%) |
| Yes | 226 (43.4%) | 220 (42.2%) |