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. 2022 Mar 28;13:847838. doi: 10.3389/fgene.2022.847838

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Copyright © 2022 Liu, Su, Zhu, Zhu, Zhu, Peng, Zhang, Wang, Hu, Chen, Chen and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential protein profile between M.tb and BCG. (A) Heatmap of proteins differentially expressed between the group of M.tb and BCG. Green-to-red scale indicates low-to-high proteins expression levels (p < 0.05). (B) Volcano plots of proteins differentially expressed between the group of M.tb and BCG. The red dots on the right indicate the significantly upregulated proteins, whereas the downregulated proteins are shown with green dots on the left. Differentially expressed proteins were defined based on a threshold fold change >1.5, at p < 0.05. (C) The top 10 KEGG pathways enriched for the significantly differentially expressed proteins. Entries with larger bubbles contain more differential genes. The color of the bubbles indicates the p value. The smaller the enrichment p value means the greater the degree of significance (p < 0.05).