Figure 5.

Males and females have distinct immune response profiles. (A) Modules with significantly different module scores between males and females. Empirical cumulative distribution function (ECDF) shown for modules scores from module 1 (left) and module 7 (right). Dashed line shows the maximum distance between distributions. Significance determined by Kolmogorov-Smirnov test, adjusted p-value <.05. (B) Mean levels of each feature in samples from female donors versus male donors. Red indicates significantly higher in females; blue, significantly higher in males; and black, not significantly different based on an FDR < 1% (SAM unpaired). (C) Boxplots of the features significantly higher in males (FDR < 1%, SAM unpaired). Features are grouped by signaling protein (black bars). Decreased IkBa plotted with male donors to reflect increased degradation of IkBa leading to higher levels of p-NFkB. (D) Boxplots of the features significantly higher in females (FDR < 1%, SAM unpaired). Features grouped by signaling protein (black bars).