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. 2022 Mar 28;9:843640. doi: 10.3389/fmolb.2022.843640

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Copyright © 2022 Guo, Li, Xu, Xu, Wang, Li, Bi, Cao, Xu, Xia, Cui and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of a CIN-related dysregulated ceRNA network. (A) CIN-related dysregulated double-weighted ceRNA network, in which mRNAs and lncRNAs were colored green and red, respectively. Node degree was indicated by the node size, and node weight and edge weight were indicated by node transparency and edge width, respectively. (B) Degree distribution of the network. Boxplots of (C) mRNA and lncRNA degree and (D) alteration of ceRNA dysregulation extent in CIN-High compared with CIN-Low samples. (E) Subnetwork CRDC connected by dense modules after screening and integration.