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. 2022 Mar 28;9:837371. doi: 10.3389/fcvm.2022.837371

Figure 3.

Figure 3

The effect of exercise on F4/80, MMP-2, TIMP, and MCP-1 levels in an early-stage model of atherosclerosis. Chow fed apoE-/- mice with early-stage plaques were exposed to exercise for 10 weeks at 12 weeks of age. Aortic sinus sections were assessed for plaque content of (A) macrophages (F4/80%), (B) monocyte chemoattractant protein-1 % (MCP-1) (C) matrix metalloproteinase-2 % (MMP-2), (D) tissue inhibitor of metalloproteinase-1 % (TIMP-1), and (E) tissue inhibitor of metalloproteinase-2 % (TIMP-2). Data are expressed as mean ± SD. The x-axis represents the control (white bar) vs. the exercise group (gray bar). Representative sections of the aortic sinus with stains for macrophage content (F4/80) [(F) control, (G) exercise], MCP-1 [(H) control, (I) exercise], MMP-2 [(J) control, (K) exercise], TIMP-1 [(L) control, (M) exercise], and TIMP-2 [(N) control, (O) exercise], with magnification x 600. *p < 0.05 **p < 0.01.