TABLE 2.

Compounds and drugs that interfere with pyroptosis.

Compound	Effect	Mechanism	Experimental Cell Lines	References
Disulfiram	Inhibitor	Prevents GSDMD hole formation	mouse iBMDM/THP-1/HEK293T	Hu et al. (2020)
Ac-FLTD-CMK	Inhibitor	inhibits GSDMD cleavage by restraining caspases-1, -4, -5, and -11	RAW 264.7/HEK-293T/THP-1	Yang et al. (2018c)
LDC7559	Inhibitor	Inhibits	HEK-293T	Sollberger et al. (2018)
		GSDMD function and blocks IL-1β release
Morroniside	Inhibitor	Inhibits cleaved caspase-1, NLRP3, and GSDMD	Primary mouse chondrocytes	Yu et al. (2021a)
Fumarate	Inhibitor	Inactivates GSDMD	BMDMs	Humphries et al. (2020)
HSP90 inhibitors	Inhibitor	Induce NLRP3 degradation through the proteasome	THP-1	Zhou et al. (2020a)
VX765	Inhibitor	Inhibits caspase-1 selectively	Microglial cells	McKenzie et al. (2018)
Polyphyllin VI	Activator	Induces NLRP3 inflammasome activation	A549/H1299	Teng et al. (2020)