TABLE 3.

The function of ncRNAs involved in pyroptosis.

NcRNAs	Name	Target Genes	Effect of Pyroptosis	Related Diseases	References
LncRNAs	lncRNA-Neat1	caspase-1	+	pneumonia	Zhang et al. (2019)
	lnc-LFAR1	NLRP3	+	liver fibrosis	Zhang. et al. (2020a)
	lncRNA-NEXN-as 1	NEXN	−	atherosclerosis	Wu et al. (2020)
	lncRNA RP11-490M8.1	TLR4/NF-κb	−	atherosclerosis	Liu et al. (2021a)
	lncRNA-RP1-85F18.6	GSDMD	−	colorectal cancer	Ma et al. (2018)
	lncRNA AA388235	caspase-3/GSDME	+	colorectal cancer	Chen et al. (2021a)
	lncRNA-Fendrr	NLRC4	+	diabetic brain I/R damage	Wang et al. (2021a)
MiRNAs	miR-141	TXNIP/NLRP3	+	intervertebral disk degeneration	Xu et al. (2020a)
	miR-148a	TXNIP	−	alcoholic liver disease	Heo et al. (2019)
	miR-125b-2-3p	NLRP1	−	hypoxic-ischemic encephalopathy	Huang et al. (2020)
	miR-181b-5p	STAT-3	−	atherosclerosis	Xu et al. (2021a)
	miR-103	BNIP3	−	atherosclerosis	Wang et al. (2020b)
CircRNAs	hsa_circ_0001836	NLRP1	−	glioma	Liu et al. (2021b)
	circACTR2	IL-1β	+	diabetic kidney disease	Wen et al. (2020)
	circ_0029589	NLRP3	−	atherosclerosis	Guo et al. (2020a)
LncRNA-related ceRNA	lncRNA-H19/miR-21	PDCD4	+	retinal ischemia/reperfusion injury	Wen et al. (2020)
	lncRNA-F630028O10Rik/miR-1231-5P	Col1a1	+	spinal cord injury	Xu et al. (2020b)
	lncRNA-MEG3/miR-223	NLRP3	+	atherosclerosis	Zhang et al. (2018)
	lncRNA MEG3/miR-485	AIM2/caspase-1	+	cerebral ischemia-reperfusion injury	Liang et al. (2020b)
	lncRNA KCNQ1OT1/miR-214-3p	caspase-1	+	diabetes cardiomyopathy	Yang et al. (2018b)
	lncRNA KCNQ1OT1/miR-214	caspase-1	+	diabetic corneal endothelial keratopathy	Zhang et al. (2020b)
	lncRNA ADAMTS9-AS2/miR-223-3p	NLRP3	+	gastric cancer	Ren et al. (2020)
	lncRNA GAS5/miR-452-5p	NLRP3/caspase-1	−	diabetic nephropathy	Xie et al. (2019)
	lncRNA ANRIL/miR-497	TXNIP	+	diabetic nephropathy	Wang et al. (2021b)
	lncRNA-HOTAIR/miR-22	NLRP3	+	hyperuricaemia	Chi et al. (2021)
	lncRNA ORLNC1/miR-200b-3p	FOXO3	+	osteoporosis	Zhang et al. (2021b)
CircRNA-related ceRNA	circ_0090231/miR-635	NLRP3	+	atherosclerosis	Ge et al. (2021)
	circHIPK3/miR-421	NLRP3	−	ischemic muscle injury	Yan et al. (2020)
	circHIPK3/miR-193a-5p	GSDMD	+	acute pancreatitis	Wang et al. (2020b)
	hsa_circ_0076631/miR-214-3p	caspase-1	+	diabetic cardiomyopathy	Yang et al. (2019b)
	circ-Calm4/miR-124-3p	PDCD6	+	pulmonary hypertension	Jiang et al. (2021)

+: pyroptosis promotion; −: pyroptosis inhibition.