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. 2022 Apr 5;10(4):e003765. doi: 10.1136/jitc-2021-003765

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Prognostic impact of the TIME score in TCGA cohort. (A) Kaplan-Meier curves for OS according to high or low T-scores, I-scores and S-scores. (B) Forrest plot to evaluate OS in TCGA lung cancer using multivariate Cox hazard proportional model analysis. (C) Kaplan-Meier curves of OS. (D) Kaplan-Meier curves of OS in T^lo (G1-4) and T^hi (G5-8) groups separately. (E) The ROC of prediction for OS of TIME score is shown comparing to CYT, cytolytic activity; TIS, Tumor Inflammatory Score, microenvironment score (xCell), immunoscore (xCell) and TNM classification. *p<0.05; **p<0.01; ***p<0.001. IFN, interferon; ns, not significant; OS, overall survival; ROC, receiver operator characteristic; TCGA, The Cancer Genome Atlas; TIME, tumor immune microenvironment; TNM, tumor, node, metastasis.