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. 2022 Mar 28;13:841062. doi: 10.3389/fimmu.2022.841062

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Copyright © 2022 Nahm, Yu, Calix and Ganaie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ficolin-2 specifically binds to serotype 11A capsule polysaccharide (PS) and demonstrates no appreciable binding to other pneumococcal surface structures. (A-C) SIM fluorescent micrographs showing DRAQ5-stained nuclei (blue) and the surface location of either 11A capsule antigens (panels A, B, first column, red), Forssman antigen (ag) on pneumococcal teichoic/lipoteichoic acid (TA/LTA) (panel C, first column, red), or bound ficolin-2 on bacteria incubated in 5% normal human serum (panels A-C, second column, green). Y-axis lists strains with respective capsule serotypes in parentheses, and X-axis lists detected structures. White scale bars depict 2µm. aTC, anhydrous tetracycline.