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. 2022 Mar 28;13:841062. doi: 10.3389/fimmu.2022.841062

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Copyright © 2022 Nahm, Yu, Calix and Ganaie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The innate, capsule-specific serological protection conferred by the ficolin-2 axis of the lectin complement pathway (LP). (A, B) The pneumococcal serotype 11A (panel A) and 11E (panel B) carbohydrate repeat units, which are polymerized into capsule polysaccharide. The dotted rectangle indicates the wcjE-dependent 6-O-acetylation (Ac) that mediates ficolin-2 recognition of 11A capsule. Blue and yellow circles represent glucose and galactose, respectively. Gro, glycerol; P, phosphate. (C) Epidemiological observations that support a model in which ficolin-2 protects against invasive pneumococcal disease (IPD) by transmissible 11A strains, while selecting for the emergence of non-transmitted 11E and 11Av clones. NP, nasopharynx; OPK, opsonophagocytic killing.