Figure 6.

Convergent evolution in the Spike gene. (a) Amino acids of S targeted in both CoV-2-D and CoV-2-G backgrounds and their frequencies in each well (open circles). (b) Non-synonymous mutations on the spike detected in the populations where the mutators were observed (number of wells on the X-axis). The color annotation represents the N-terminal domain (NTD, 14–305), the receptor-binding domain (RBD, 319–541), the cleavage site (S1/S2, 669–688), the fusion peptide (FP, 788–806), the heptapeptide repeat sequences (HR1, 912–984 and HR2, 1163–1213), the TM domain (1213–1237) and cytoplasm domain (CP, 1237–1273)