TABLE 1.
Ranges of MICs of several antibiotics for MLSB-susceptible and C-MLSB-resistant MSSA and MRSA isolatesa
| Antibiotic | MIC range (mg/liter)
|
|||
|---|---|---|---|---|
| MSSA MLSB-S | MSSA C-MLSB-R | MRSA MLSB-S | MRSA C-MLSB-R | |
| Q-D | 0.25–0.5 | 0.25–1 | 0.25 | 0.25–0.5 |
| Quinupristin | 1–4 | 32 | 1–4 | 32 |
| Dalfopristin | 1–4 | 1–8 | 1–4 | 1–8 |
| Flucloxacillin | 0.06–0.012 | 0.06–0.012 | 0.12–>64 | 0.12–>64 |
| Amoxicillin | 0.25–>64 | 0.25–>64 | >64 | >64 |
| Cefuroxime | 1 | 1 | >64 | 8–>64 |
| Cefamandole | 0.25–0.5 | 0.25–1 | 4–16 | 2–8 |
| Cefepime | 0.25–1 | 0.25–1 | >64 | >64 |
| Imipenem | 0.01–0.03 | 0.01–0.03 | 4–16 | 4–16 |
| Vancomycin | 0.5–1 | 0.5–1 | 2 | 1–2 |
| Rifampin | 0.004 | 0.004 | 0.004–>1 | 0.004–>1 |
| Tetracycline | 0.25 | 0.25–>64 | >64 | 32–>64 |
| Co-trimoxazole | 0.25–4 | 0.25 | 2–>8 | 2–>8 |
| Ciprofloxacin | 0.125–0.5 | 0.06–0.25 | 0.12–16 | 0.12–0.25 |
| Gentamicin | 0.125–0.5 | 0.06–16 | 6–32 | 8–32 |
a
The MSSA isolates include four MLSB-susceptible (MLSB-S) and four C-MLSB-resistant (C-MLSB-R) clinical isolates; the MRSA isolates include five MLSB-susceptible and five C-MLSB-resistant clinical isolates.