Table. 3:
Remission, response, and non-response following TMS treatment in geriatric depression (GD) for randomized controlled trials (RCTs) and uncontrolled trials.
| Author and year | n | Responders | p | Remitters | p |
|---|---|---|---|---|---|
| Randomized Control Trials | |||||
| Manes et al. 2001 | 20 (sham=10) | Active group: 3, sham group: 3 (50% or greater decrease in HDRS score & no longer meeting criteria for major or minor depression). | n.s. | Active group: 2, sham group: 2 (HDSR score ≤ 8). | n.s. |
| Mosimann et al. 2004 | 24 (sham=9) | Active group: 1, sham group: 0 (Decrease in HDSR score ≥ 50%). Partial responders, active group: 3, sham group: 2 (Decrease in HDSR score ≥ 30%). |
n.s. n.s. |
- | - |
| Jorge et al. 2008 | 30 (sham=15) | Active group: 5, sham group: 1 (Decrease in HDSR score ≥ 50%). | 0.08 (n.s.) | Active group: 2, sham group: 1 (HDSR score ≤ 8 & no longer meeting criteria for major or minor depression). |
0.50 (n.s.) |
| Jorge et al. 2008 | 62 (sham=29) | Active group: 13, sham group: 2 (Decrease in HDSR score ≥ 50%). | 0.03 | Active group: 9, sham group: 1 (HDSR score ≤ 8 & no longer meeting criteria for major or minor depression). | 0.01 |
| Kaster et al. 2018 | 52 (sham=27) | Active group: 11, sham group: 5 (Decrease in HDSR score ≥ 50% relative to baseline on 2 consecutive weeks). | <0.05 | Active group: 10, sham group: 4 (HDSR score ≤ 10 & ≥ 60% reduction from baseline for 2 consecutive weeks). | <0.05 |
| Trevizol et al. 2019 | 43 (sham=12) | Active group: 9, sham group: 2 (Decrease in HDSR score ≥ 50%). | 0.016 | Active group: 8, sham group: 0 (HDSR score ≤ 10). | 0.004 |
| Lebhluber et al. 2019 | 29 (sham=10) | - | - | - | - |
| Uncontrolled Trials | |||||
| Mosimann et al. 2002 | 13 | - | - | ||
| Nahas et al. 2004 | 18 | 5 (Decrease in HDSR score ≥ 50%). | 4 (HDSR score < 8). | ||
| Fabre et al. 2004 | 11 | 5 (Decrease in HDSR score ≥ 25%). | - | ||
| Abraham et al. 2007 | 19 | 6 (Decrease in HDSR score ≥ 50%). | 2 (HDSR score < 8). | ||
| Milev et al. 2009 | 49 | 16 (Decrease in HDSR score ≥ 30%). | 4 (HDSR score < 8). | ||
| Dardenne et al. 2017 | 10 | 4 (Decrease in HDSR & BDI scores ≥ 50%). | 2 (HDSR score ≤ 7 & BDI score ≤ 5). | ||
| Sayar et al. 2019 | 70 | 38 (Decrease in HDSR score ≥ 50%). | 19 (HDSR score < 8). | ||