Table 2.

The structures of PROTAC molecules targeting cell proliferation in cancers. (red: POI ligand; yellow: E3 ligand)

Target	PROTAC	PROTAC structure	Cancer	Ref	Target	PROTAC	PROTAC structure	Cancer	Ref
BRD4	ARV-825		BL	[39]	BRD4	SNIPER(BRD4)-1		BC	[89]
BRD4	dBET1		AML	[12]	BRD4	A1874		CRC, M, BL, et al.	[90]
BRD4	MZ1		CC	[33, 91]	BRD4	CLIPTAC-BRD4		CC, M, CRC	[26]
BRD4	dBET6		T-ALL	[92]	BRD4	opto-dBE T1		MM, PC, ALCL, et al.	[22]
BRD4	ZXH-3-26		MM	[93]	BRD4	PROTAC4		BC, PC	[23]
BRD4	ARV-771		PC	[76]	BRD4	pc-PROTAC1		BL, HCC	[25]
BRD4	macroPROTAC-1		PC, AML	[94]	BRD4	PHOTAC-I-3		ALL	[21]
BRD4	BETd-246		TNBC	[95]	BRD4	photoPROTAC-1		BL	[20]
BRD4	BETd-260		AML, ALL	[96]	BRD4	PROTAC3		CC	[24]
BRD4	KB02-JQ1		/	[97]	EGFR	compound 1		OC, CC	[79]
BRD4	XH2		BC	[98]	EGFR	compound 14o		NSCLC	[99]
BRD4	DP1		DLBCL	[100]	EGFR	compound P3		LC	[101]
CDK4/6	BSJ-03-123		AML	[102]	EGFR	MS154		LC	[103]
CDK4/6	pal-pom		TNBC	[104]	EGFR	DDC-01-163		LC	[80]
CDK4/6	BSJ-02-162		MCL	[77]	AURORA-A	JB170		AML, OS, NB, HCC	[81]
CDK4/6	BSJ-04-132		T-ALL	[77]	Raf	P4B		M, CRC	[60]
CDK4/6	YX-2-107		ALL	[78]	AR	PROTAC 14		CC	[7]
CDK4/6	compound 11		M	[105]	AR	ARCC-4		PC	[106]
CDK4/6	PROTAC 34		ALL, AML, MM, TNBC	[107]	AR	TD-802		PC	[108]
AR	MTX-23		PC	[109]	BRD7/9	ACBI1		AML, M, NSCLC	[83]
AR	ARD-69		PC	[110]	CDK2/5	TMX-2172		OC	[84]
AR	SNIPER(AR)-51		PC	[111]	CDK8	JH-XI-10-02		T-ALL	[112]
ALK	MS4077		NSCLC, ALCL	[113]	CDK9	PROTAC 3		CRC	[114]
ALK	TL13–12		ALCL, NB, NSCLC	[52]	CDK9	THAL-SNS-032		T-ALL	[38]
ALK	opto-dALK		NSCLC, ALCL	[22]	CDK9	B03		AML	[115]
ALK	SIAIS117		NSCLC, ALCL	[116]	CDK9	compound F3		PC	[117]
BLK	PROTAC 7		CML	[118]	Cdc20	CP5V		BC	[119]
BRD7/9	dBRD9		AML	[82]	c-Met	PROTAC 7		TNBC, GC	[79]
BRD7/9	VZ185		MRT	[120]	CREPT	PRTC		PaC	[121]
CYP1B1	compound 6C		PC	[122]	MEK1/2	MS432		CRC, M	[86]
DHODH	probe 10		PaC	[123]	Ras	LC-2		NSCLC, PaC	[87]
ER	ERD-308		BC	[124]	GSPT1	CC-885		AML	[125]
ER	compound I-6		BC	[126]	PLK1	HBL-4		AML	[127]
ER	TD-PROTAC		BC	[128]	SLC9A1	d9A-2		CML	[129]
ER	SNIPER(ER)-87		BC	[89]	TACC3	SNIPER(TACC3)-1		FS, OS, CRC	[130]
ERK1/2	ERK-CLIPTAC		CC, M, CRC	[26]	TRIM 24	dTRIM24		AML	[131]
FLT-3	FLT-3 PROTAC		AML	[132]	TRKA/C	CG416		CRC, AML	[133]
HER2	PROTAC 1		OC, BC	[79]	Wee1	ZNL-02-096		OC, T-ALL	[88]
MEK1/2	compound 3		M	[85]	α1A-AR	α1A-AR		PC	[134]