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. 2022 Apr 11;21:99. doi: 10.1186/s12943-021-01434-3

Table 4.

The structures of PROTAC molecules targeting cancer immune evasion or inflammation. (red: POI ligand; yellow: E3 ligand)

Target PROTAC PROTAC structure Cancer Ref Target PROTAC PROTAC structure Cancer Ref
PD-L1 P22 graphic file with name 12943_2021_1434_Figdt_HTML.gif NSCLC TNBC, M [215] FKBP12 dFKBP-1 graphic file with name 12943_2021_1434_Figdu_HTML.gif AML [12]
BTK DD-04-015 graphic file with name 12943_2021_1434_Figdv_HTML.gif DLBCL [161] FKBP12 dTAG-13 graphic file with name 12943_2021_1434_Figdw_HTML.gif AML [225]
BTK P13I graphic file with name 12943_2021_1434_Figdx_HTML.gif BL, DLBCL, MCL [216] FKBP12 RC32 graphic file with name 12943_2021_1434_Figdy_HTML.gif T-ALL, BL, PC, BC, CC [226]
BTK RC-3 graphic file with name 12943_2021_1434_Figdz_HTML.gif BL, MCL, CML [217] FKBP12 KB02-SLF graphic file with name 12943_2021_1434_Figea_HTML.gif / [97]
BTK RC-1 graphic file with name 12943_2021_1434_Figeb_HTML.gif AML, MCL [227] HPK1 SS44 graphic file with name 12943_2021_1434_Figec_HTML.gif

BL, MM,

CML, et al

 [220]
BTK BC5P graphic file with name 12943_2021_1434_Figed_HTML.gif AML [219] IDO1 degrader 2c graphic file with name 12943_2021_1434_Figee_HTML.gif CC [221]
BTK DD-03-171 graphic file with name 12943_2021_1434_Figef_HTML.gif MCL, DLBCL [218] IKZF1/3 DD-03-171 graphic file with name 12943_2021_1434_Figeg_HTML.gif MCL, DLBCL [218]
BTK compound 10 graphic file with name 12943_2021_1434_Figeh_HTML.gif BL, AML [228] IRAK4 degrader-5 graphic file with name 12943_2021_1434_Figei_HTML.gif DLBCL [229]
BTK PROTAC 7 graphic file with name 12943_2021_1434_Figej_HTML.gif BL, CML [118] ITK TL12-186 graphic file with name 12943_2021_1434_Figek_HTML.gif AML, T-ALL [161]
STAT3 SD-36 graphic file with name 12943_2021_1434_Figel_HTML.gif AML, ALCL [57] JAK JP-6 graphic file with name 12943_2021_1434_Figem_HTML.gif AML [222]
CD147 compound 6a graphic file with name 12943_2021_1434_Figen_HTML.gif M [230] Lin28 ORN3P1 graphic file with name 12943_2021_1434_Figeo_HTML.gif CML [18]
PDE4 SNIPER(PDE4)-9 graphic file with name 12943_2021_1434_Figep_HTML.gif FS [89] PRC2 PROTAC 1 graphic file with name 12943_2021_1434_Figeq_HTML.gif DLCBL [231]
PDEδ compound 17f graphic file with name 12943_2021_1434_Figer_HTML.gif CRC [232] PRMT5 MS4322 graphic file with name 12943_2021_1434_Figes_HTML.gif BC [233]
PDEδ PROTAC 3 graphic file with name 12943_2021_1434_Figet_HTML.gif T-ALL, PaC, CC [234] Rpn13 WL-40 graphic file with name 12943_2021_1434_Figeu_HTML.gif MM [235]
Pirin CCT367766 graphic file with name 12943_2021_1434_Figev_HTML.gif OC [236] SHP2 SHP2-D26 graphic file with name 12943_2021_1434_Figew_HTML.gif EC, AML [223]
PRC2 UNC6852 graphic file with name 12943_2021_1434_Figex_HTML.gif CC, DLCBL [237] TBK1 PROTAC 3i graphic file with name 12943_2021_1434_Figey_HTML.gif NSCLC [238]