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. Author manuscript; available in PMC: 2022 Apr 11.
Published in final edited form as: J Orthop Res. 2017 Jul 18;35(12):2658–2666. doi: 10.1002/jor.23587

FIGURE 1.

FIGURE 1

Sustained inflammation model and drug delivery by hydrogel. a. Hydrogel is mixed with methylene blue, to demonstrated localized release, or LPS, to induce sustained inflammation and injected percutanously over the calvaria. b. Scanning electron microscopy of hydrogel after 30mins and 7 days to demonstrate physical breakdown of gel corresponding to the release kinetics of CRT from the gel (right). c. Methylene blue loaded hydrogel displayed persistent localized release over 7 days. d. LPS loaded hydrogel instigates sustained inflammation leading to progressive bone resorption on the mouse calvaria.