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. 2022 Apr 11;149(6):1949–1957. doi: 10.1016/j.jaci.2022.04.002

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Fig 2 — SARS-CoV-2–specific binding antibodies. A, Levels (GMT ± 95% CI) of total RBD-specific immunoglobulins at baseline (pre), after vaccination 1 (post 1), and after vaccination 2 (post 2) in all different patients with PID. Symbols show individual data points, violin plots reflect data distribution, and lines connect the GMT. B, Comparison of total RBD-specific immunoglobulins (GMT ± 95% CI) after vaccination 1 (left panel) and after vaccination 2 (right panel) between groups. Lower level of detection is a ratio of 0, and responder (resp) cutoff is a ratio of 1 (black dotted line). A ratio of 18 is the maximum dynamic range of the assay. Number of participants above responder cutoff is indicated beneath the x-axis. C, Comparison of S-specific antibodies (GMT ± 95% CI) after vaccination 2 between groups. LLoD is 1 BAU/mL, and responder (resp) cutoff is set at 22.87 BAU/mL (black dotted line). Number of participants above responder cutoff is indicated beneath the x-axis. Patients with IgG deficiencies and patients with SPAD are combined in panels B and C, but the original color coding (A) is maintained. Color coding is the same in all (Online Repository) figures. def, Deficiency; LLoD, lower level of detection; phag, phagocyte; PID, primary immunodeficiency; undef, undefined.