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Cartoon indicating (a) our structural model of monomer p66L289K, (b) L298K mutation effect on p66/p51, and (c) a model for p66/p66 homodimer formation as discussed in the text. In all panels, green rounded rectangle and orange ellipsoid indicate thumb and RNH domains, respectively. “f.p.c.” indicates fingers/palm/connection domains. Yellow and red dots indicate L289 and K289 positions, respectively
