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. Author manuscript; available in PMC: 2022 Apr 11.
Published in final edited form as: Free Radic Biol Med. 2022 Feb 1;181:52–61. doi: 10.1016/j.freeradbiomed.2022.01.030

Fig. 2.

Fig. 2.

Metformin alters the expression of genes related to autophagy, aging, and stress response in a C. elegans model of ALS. (A) Quantification of gene expression in hS0DlG93A transgenic worms fed metformin or treated with RNAi, hSOD1G93A worms without treatment served as the control. Metformin reduced hSOD1 expression in hSOD1G93A worms and increased Lisal of genes related to autophagy, lifespan, and stress response. (B) Quantification of gene expression in DA2123 worms. #P<0.01 (vs. control), **P<0.001,*P<0.01 (vs. hSOD1G93A). N ~ 1000 worms per condition front 3 independent experiments.