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. Author manuscript; available in PMC: 2022 Apr 11.
Published in final edited form as: Free Radic Biol Med. 2022 Feb 1;181:52–61. doi: 10.1016/j.freeradbiomed.2022.01.030

Fig. 5.

Fig. 5.

Schematic for the metformin extends lifespan and ameliorates motor deficits in an ALS C. elegans model. (A) The addition of metformin activates the autophagy and daf-16 pathways in C. elegans and upregulates autophagy and longevity genes in vivo, such as lgg-1 and daf-16. Increased autophagic activity promotes the degradation of toxic substances, enhances stress response and promotes longevity. (B) Schematic of interactions between the sod-1, lgg-1 and daf-16 genes in ALS C. elegans.