Title {1}	Efficacy and safety of lumbrokinase plus aspirin versus aspirin alone for acute ischemic stroke (LUCENT): study protocol for a multicenter randomized controlled trial
Trial registration {2a and 2b}.	Chinese Clinical Trial Registry, which is the primary registry of the WHO International Clinical Trial Registration Platform, ChiCTR2000032952. Registered on May 16, 2020. URL: http://www.chictr.org.cn/index.aspx
Protocol version {3}	Version 2.0 of 28-12-2019
Funding {4}	National Science Fund for Distinguished Young Scholars, China (No.81725024)
Author details {5a}	Ying Chen: Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Beijing University of Chinese Medicine, Beijing 100029, China Yan Liu: Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China Jingjing Zhang: Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Beijing University of Chinese Medicine, Beijing 100029, China Kehua Zhou: Department of Hospital Medicine, ThedaCare Regional Medical Center-Appleton, Appleton, WI 54911, USA Xuecheng Zhang: Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Beijing University of Chinese Medicine, Beijing 100029, China Hengheng Dai: Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Beijing University of Chinese Medicine, Beijing 100029, China Baolin Yang: Department of Encephalopathy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China Hongcai Shang: Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Name and contact information for the trial sponsor {5b}	Investigator initiated clinical trial;Hongcai Shang (Principal Investigator)shanghongcai@126.com
Role of sponsor {5c}	This is an investigator initiated clinical trial. Therefore, the funders played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.